Western Medicine Omeprazole Sodium for Injection for I. M/I. V
Drugs Inhibiting Gastric Acid Secretion
Each vial contains:
Omeprazole equivalent to 40mg
Omeprazole is a substituted benzimidazole that suppresses gastric
acid secretion by specific inhibition of the H'/K' ATP ase enzyme
system (proton pump) at the secretory surface of the gastric
parietal cell thus blocking the final step of acid production.
It is indicated for disorders associated with hypersecretion of
gastric acid such as benign gastric ulcers, duodenal ulcers ,
gastroesophageal reflux disease and Zollinger-Ellison syndrome.
Hypersensitivity to the components of the formulation.
Warnings and Precautions
Drugs metabolised in the liver:
Omeprazole can prolong the elimination of diazepam , warfarin and
phenytoin which are metabolised by oxidation in the liver.
Hence , at the time of concomitant administration , dosage
adjustment should be done after careful monitoring of the patient.
Ketoconazole, ampicillin esters and iron salts : Because of its
profound and long lasting inhibition of gastric acid secretion,
omeprazole may interfere with the absorption of those drugs where
is an important determinant of their bioavailability.
There are no adequate or well controlled studies of omeprazole in
pregnancy. Hence a decision should be made by taking into account
the benefits offered and the potential risk involved.
It is not known whether omeprazole is secreted in breast milk. But
becasue of the potential for adverse effects , a decision should be
made whether to discontinue nursing or to discontinue the drug,
account the importance of the drug to mother.
Safety and effectiveness has not been established.
Symptomatic response to therapy with omeprazole does not preclude
the presence of gastric malignancy.
Nausea , headache , diarrhoea , constipation and flatulence are
reported but occur rarely. These events are mild and transient and
there has been no consistent relationship with treatment.