Western Medicine METRONIDAZOLE Injection 500mg/100ml (For serious
infections caused by susceotible anaerobic bacteria)
For IV infusion only.
Each Metronidazole IV RTU (Ready-To-Use) 100-ml single-dose
contains a sterile,nonpyrogenic,isotonic,buffered solution of 500mg
Treatment of Anaerobic Infections: Metronidazole is indicated in
the treatment of serious infections caused by susceotible anaerobic
bacteria.Indicated surgical procedures should be performed in
conjunction with Metronidazole theraoy. In a mixed aerobilc and
anaerobic injection, antobiotocs appropriate for the treatment of
the aerobic infection should be used in addition to Metronidazole.
Metronidazole is effective in Bacteroides fragllis infections
resistant to clindamycin,chioramphenicol,and penicillin.
DOSAGE AND ADMINISTRATION
In elderly patients the pharmacokinetics of metronidazole may be
altered and therefore monitoring of serum levels may be necessary
to adjust the metronidazole dosage accordingly.
Treatment of Anaerobic injections.
The recommended dosage schedule for adults is:
Loading Dose:15mg/kg infused over one hour (approximately 1g for a
Maintenance Dose:7.5mg/kg infused over one hour every six hours
(approximately 500mg for 70-kg adult).The first maintenance dose
should be instituted six hours following th initiation of the
A maximum of 4g should not be exceeded during a 24-hour period.
Patients with severe hepatic disease metabolize metronidazole
slowly with resultant accumulation of metronidazole and its
metabolites in the plasma.Accordingly for such patients,doses below
those usually recommended should be administered catiously.Close
monitoring plasma metronidazloe level 1 and toxicity is
In patients receiving Metronidazole in whom gastric secretions are
continuously removed by nasogastric aspiration,sufficient
Metronidazole may be removed in the aspirate to cause a reduction
in serum levels.
The dose of Metronidazole should not be specifically rescued in
anuric patients since accumulated metabolites may be rapidly
removed by dialysis.
The usual duration of therapy is 7 to 10 days;however,infections of
the bone and joint,lower respiratory tract,and endocardium may
require longer treatment.
Metronidazole is to be administered by slow intravenous drip
infusion only,either as a continuous or intermitten infusion.IV
admixtures containing metronidazole and other drugs should be
avoided.Additives should not be introduce into the Metronidazole IV
RTU solution.If used with a primary intravenous fluid system,the
primary solution should be discontinued during metronidazole
Hypersensitivity to metronidazole ot its any component.
Convulsivwe Seizures and Peripheral Neuropathy,
Convulsivwe seizures and peripheral neuropathy, the latter
characterized mainly bb numbness or paresthesiaa of an
extremity,have been reported in patients treated with
metronidazole.The appearance of abnormal neurologic signs demands
the prompt discontinuation of Metronidazole therapy.Metronidazole
should be administered with caution to patients with central
nervous system disease.
Store at room temperature (below 30°C)
Protect from light,heat and moisture
Use as directed by the Physician
Keep out of the reach of children.
A vial of 100ml containing Metronidazole 500mg.
|Characteristics||Light yellow liquid||Complies|
|Identification||Should Positive reaction||Complies|
|Uniformity of weight||Meet the specification||Complies|
|Visible foreign matter||Meet the requirements||Complies|
|Microbial Contamination||Meet the specification||Complies|
|Related substances||Meet the specification||Complies|
|【CONCLUSION】||The above product confirms to USP27|