Ampicillin is indicated for the treatment of severe infections
where the causative organism is unknown, and for mixed infections
involving β-lactamase-producing staphylococci. Typical indications
In general practice: Chest infections, ENT infections, skin and soft tissue infections,
and infections in patients whose underlying pathology places them
at special risk.
In hospital (prior to laboratory results being available): severe respiratory
tract infections, post-operative chest and wound infections, septic
abortion, puerperal fever; septicaemia, prophylaxis in major
surgery, infections in patients receiving immuno-suppressive
The spectrum of activity of co-fluampicil also makes it suitable
for the treatment of many mixed infections, particularly those
where β-lactamase-producing staphylococci are suspected or
Parenteral usage is indicated where oral dosage is inappropriate.
Dosage and Administrations:
Adults and Children:
Give IV inj slowly over at least 10–15 minutes; rapid IV
administration may result in convulsive seizures. Respiratory tract
and soft tissue infections: <40kg: 25–50mg/kg per day in equally
divided doses every 6–8 hours. ≥40kg: 250–500mg every 6 hours. GI
or GU tract infections (including N. gonorrhoeae in women): <40kg: 50mg/kg per day in equally divided doses
every 6–8 hours. ≥40kg: 500mg every 6 hours. Urethritis in males
due to N. gonorrhoeae: two doses of 500mg each at interval of 8–12 hours. Meningitis:
Initiate with IV drip, then continue IM. 150–200mg/kg per day in
equally divided doses every 3–4 hours. Septicimia: Initiate IV for
at least 3 days, then continue IM every 3–4 hours. 150–200mg/kg per
day; treat for at least 10 days if caused by Group A β-hemolytic
Cephalosporin, imipenem, other allergy or mononucleosis: not
recommended. Monitor blood, renal, and liver function in long-term
use. Pregnancy (Cat.B). Nursing mothers.
May cause false (+) glucose test with Clinitest, Benedict's or
Fehling's soln. Potentiated by probenecid. May increase risk of
rash with allopurinol.
Anaphylaxis, urticaria, GI upset, blood dyscrasias.
1g/vial, 50vials/box, 20boxes/carton
Store below 30 centigrade degree, protect from light and moistures.
keep it in the reach out of children.